Does Bariatric Surgery Improve Adipose Tissue Function?

Bariatric surgery is one of the most effective and well-known treatments for obesity. Although it is more commonly known as weight loss surgery, it is not exclusively used for delivering significant results of weight reduction. Bariatric surgery also enhances the effects that insulin has on the bodies metabolic capacity. In other words, the ability of insulin being absorbed by the body.

The main objective of this review is to understand and investigate how the physiology of adipose tissue changes within the body. Specifically, the intensity of metabolic impact that bariatric surgery has on the body.

What is Adipose Tissue?

Adipose tissues function is basically a “warehouse” to store energy within the body as fat. Besides storing energy, adipose tissue gives the body proper insulation to function effectively. The capacity of individual adipocytes, or body fat, is connected through fat tissue and other key metabolic tissues.  Fat tissues locations are underneath the skin, around the kidneys, back of the eyeballs, and around the heart.

Adipose Tissue Function

 

Obesity and Adipose Tissues

Small adipocytes (cells that compose adipose tissues) in lean individuals promote metabolic regulation of the body. Both number and size of adipose tissues in obese individuals are larger than lean individuals. The enlarged adipocytes of obese individuals:

  1. Recruit (MI-activated) macrophages and causes inflammation
  2. They release a range of Tumor Necrosis Factor-α (TNF-α), which recruits and activates additional immune cells to the site
  3. Originate predisposition toward insulin resistance

Bariatric and Metabolic Surgery

Bariatric surgery is broadly recognized as the best treatment for obesity, and escalated endeavors in the course of recent years have added to our comprehension. Now we understand the components by which weight loss surgery enhances metabolism and resolves or cures type 2 diabetes in patients.

Yet, we have moved our comprehension of how metabolism is controlled. We notice mechanical clarifications as a significant achievement of bariatric surgery. For example, confinement of stomach volume and intestinal malabsorption have offered an approach to physiological clarifications that accentuate adjustments in gut signs to different organs. A key inquiry is how much these signs have immediate or aberrant effects on fat tissue metabolic capacity.

A developing assortment of proof connections fat tissue brokenness to key parts of the metabolic dysregulation that goes with overabundance body weight. Therefore, our point with the present survey is to give a review of how fat tissue reacts to bariatric surgery and whether there is weight reduction autonomous instruments associated with these reactions.

Bariatric Surgery Procedures

Bariatric surgical methodology induces weight reduction by limiting the amount of nourishment that the stomach can hold, malabsorption of supplements, or by a mix of both gastric restriction and malabsorption. Bariatric methods additionally cause hormonal changes. Most weight reduction surgeries today are performed utilizing insignificantly obtrusive and minimally invasive methods (laparoscopic surgery).

The two predominant bariatric procedures utilized as a part of the Mexico Bariatric Center operation are Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (VSG).

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Roux-en-Y Gastric Bypass

Roux-en-Y Gastric Bypass Surgery

The RYGB leaves the patient with a little stomach pocket under the esophagus, and the gut nutrients are re-routed to such an extent that supplements are redirected from the upper to the lower of the small digestive tract. RYGB incites noteworthy weight reduction as well as enhances insulin protection with abatement of sort 2 diabetes much of the time.[/one_half]

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Vertical Sleeve Gastrectomy

Vertical Sleeve Gastrectomy

Vertical sleeve gastrectomy (VSG) is an anatomically more straightforward task, including expelling around 80% of the stomach along the more prominent ebb and flow, leaving intestinal anatomy unaltered. The gastric sleeve helps the patient feel fuller faster and stay full for longer periods of time, resulting in significant weight loss by eating less food.[/one_half_last]

 

This methodology was, some time ago, accepted to be viable exclusively as a result of malabsorptive and prohibitive properties. This worldview has changed over the past decade, confirming adjustments in gut nutrients effectively improves physiology modifications in gut hormone discharge imperative for managing and sustaining digestion. From the restrictive and malabsorptive perspective, vertical sleeve gastrectomy (VSG) would be relied upon to be substandard compared to Roux-en-Y gastric bypass (RYGB) in light of the fact that it includes a bigger gastric supply and no intestinal bypass. Amazingly, the adequacy of VSG isn’t a long way from RYGB.

What Does Bariatric Surgery do to Adipose Tissue

Apart from the physical reduction of fat mass, bariatric surgery circulates the fat from instinctive compartments where they usually build up, to subcutaneous compartments which favor metabolic change. This means that bariatric surgery displaces the fat tissue from existing, built-up sections of the body to other sections with more a metabolism to burn the fat.

Impact of Bariatric Surgery

The affectability toward lipolysis (the breakdown of fats controlled by insulin), and catecholamines (the bodies response to stress), are both enhanced by bariatric surgery. The protein signaling cells known as adipokine emission is adjusted while the fat aggravation and incendiary markers diminish. Some of these progressions have been appeared to be free of weight reduction, and novel theory for these impacts incorporate changes in bile corrosive digestion, gut microbiota, and focal direction of digestion.

Ultimately, bariatric surgery is equipped for enhancing aspects of how fat tissue works within the body. Most of these positive changes have not been clarified by the powerful impact of bariatric surgery.

Conclusion

Every surgery has some positive impact so here, it is applicable to both the gastric bypass and gastric sleeve surgeries. Both weight loss operations are effective for 60-80% excessive weight loss. Both cause favorable changes in gut hormones that suppress hunger, reduce appetite, and enhance satiety. They restrict the amount of food that stomach can hold.

The current studies suggest that bariatric surgery reduces the mass of Visceral Adipose Tissue (VAT), improves the circulating adipokines, and reduces lipid accumulation in the liver and blood. Adipose tissue has a crucial role in organism longevity and energy usage as it interacts with multiple metabolic target organs. Taking everything into account, bariatric surgery’s effect on fat cells is likely an essential element to the success of surgery, however, the mechanism is not by any stretch of the imagination clarified.

Global Healthcare and Bariatric Surgery

Surgical treatment for obesity, or bariatric surgery, is a proven method for rapid and long-term weight loss as well as resolving comorbidities associated with obesity. However, the high cost of these procedures prohibits countries like the United States and Canada to offer this life-saving solution to the overweight and obese population. Outbound Medical Tourism, travel outside of the country to receive medical treatments, is becoming a viable option for the overweight and obese patients. Medical tourism in Mexico is the most prominent option as the surgical centers and surgical staff is offering the same or better services at a fraction of the cost. For example, Mexico Bariatric Center offers all-inclusive from arrival to departure gastric sleeve for less than of $5,000 for an average saving of 75% in U.S. and Canada. MBC is one of the only companies that offer Bariatric and Metabolic Board-Certified surgeons, dedicated bariatric hospital, surgeon liaison, a comprehensive after-care program with 2 nights hospital and 2 nights hotel stay.

Mexico Bariatric Center

(855)768-7247

References:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328428/

By |2018-06-08T23:56:28+00:00February 12th, 2018|Mexico Bariatric Center News|0 Comments

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